The sizes of the data markers indicate the weight of each trial. AAA indicates the Aspirin for Asymptomatic Atherosclerosis trial; APLASA, the Antiphospholipid Antibody Acetylsalicylic Acid study; ARRIVE, the Aspirin to Reduce Risk of Initial Vascular Events study; ASCEND, A Study of Cardiovascular Events in Diabetes; ASPREE, the Aspirin in Reducing Events in the Elderly trial; ECLAP, the European Collaboration on Low-Dose Aspirin in Polycythemia Vera; HOT, the Hypertension Optimal Treatment Study; JPAD, the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes Trial; JPPP, the Japanese Primary Prevention Project; POPADAD, the Prevention of Progression of Arterial Disease and Diabetes trial; PPP, the Primary Prevention Project; and WHS, the Women’s Health Study.