The sizes of the data markers indicate the weight of each trial. AAA indicates the Aspirin for Asymptomatic Atherosclerosis trial; APLASA, the Antiphospholipid Antibody Acetylsalicylic Acid study; ARRIVE, the Aspirin to Reduce Risk of Initial Vascular Events study; ASCEND, A Study of Cardiovascular Events in Diabetes; ASPREE, the Aspirin in Reducing Events in the Elderly trial; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); JPAD, the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes Trial; JPPP, the Japanese Primary Prevention Project; POPADAD, the Prevention of Progression of Arterial Disease and Diabetes trial; RR, relative risk; and WHS, the Women’s Health Study.