Table 2.
Main parameters of various formulations after administration in rabbit’s eye (n = 4)
| Parameter | CBs | CBLs | P-CBLs |
|---|---|---|---|
| AUC (0–t) (ng/mL) | 40,780.94 ± 9715.737 | 54,294.446 ± 13,066.52 | 67,033.93 ± 9105.516** |
| AUC (0–∞) (ng/mL) | 43,825.184 ± 10,967.05 | 61,824 ± 45,069.22 | 12,314.38 ± 69,431.46* |
| Tmax (min) | 45 ± 10 | 80 | 130 ± 47.61 |
| Cmax (ng/mL) | 323.9 ± 121.4 | 556.895 ± 56.859* | 400.023 ± 108.757*# |
| t1/2z | 131.442 ± 162.889 | 2326.416 ± 4563.18 | 241.006 ± 168.415 |
* P < 0.05, ** P < 0.01, compared with CBs; # P < 0.05, compared with CBLs