Table 3.
Conditional and post-test probability performance of the IHC based prediction model in the training and validation cohort
| Training cohort | Validation cohort Responder: PR | Validation cohort Responder: PR + SD | |
|---|---|---|---|
| Prevalence (responder) | 63.3 (49.9–75.4) | 26.1 (10.2–48.4) | 56.5 (34.5–76.8) |
| Sensitivity | 86.8 (71.9–95.6) | 33.3 (4.3–77.7) | 15.4 (1.9–45.5) |
| Specificity | 63.6 (40.7–82.8) | 82.4 (56.6–96-2) | 70.0 (34.6–93.3) |
| LR+ (weighted by prevalence) | 2.39 (1.36–4.21) | 1.89 (0.41–8.71) | 0.51 (0.10–2.51) |
| LR- (weighted by prevalence) | 0.21 (0.09–0.50) | 0.81 (0.44–1.49) | 1.21 (0.76–1.93) |
| PPV | 80.5 (70.1–87.9) | 40.0 (12.6–75.5) | 40.0 (12.0–76.5) |
| NPV | 73.7 (53.8–87.1) | 77.8 (65.6–86.5) | 38.9 (28.5–50.4) |
Data are expressed as percentages, except LR+ and LR- (odds), with 95% confidence intervals. Abbreviations: LR+ positive likelihood ratio, LR- negative likelihood ratio, PPV positive predictive value, NPV negative predictive value