Table 1.
Characteristics of the seven-CpG panel
| Probe ID | Chr. | Relevant gene symbol | Relation to gene region | Relation to CpGs islandb | Multivariate Cox coefficientsa |
|---|---|---|---|---|---|
| ᅟcg23904249 | 11 | CCDC86 | TSS1500 | Shore | 1.095 |
| cg07490776 | 8 | AP3M2 | TSS1500 | Island | 1.575 |
| cg24035962 | 10 | NCOA4 | TSS200 | Island | − 1.365 |
| cg26647453 | 4 | C4orf17 | 5′UTR | Open sea | − 1.574 |
| cg01980222 | 6 | TREM2 | 1stExon | Open sea | − 1.248 |
| cg15227610 | 11 | HSPB2 | TSS1500 | Open sea | − 1.120 |
| cg13784557 | 6 | HCP5 | TSS200 | Open sea | − 0.975 |
Chr chromosome, TSS transcriptional start site
aCox coefficients were calculated from multivariate analysis incorporating age, different discovery sets, MGMT methylation status, and the seven CpGs within the combined RT/TMZ discovery cohorts
bOpen sea and shore refers to regions away from relevant CpGs islands more than 4000 bp or less than 2000 bp, respectively