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. 2018 Oct 8;471(3):507–517. doi: 10.1007/s00424-018-2211-3

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Physiological significance of canonical transient receptor potential (TRPC) channels in exercised human body. Exercise may increase the abundance of TRPCs and Nox proteins in skeletal muscle, while it may downregulate TRPC3 and Nox2 in the heart. Exercise-induced upregulation of TRPCs is concomitant with the upregulation of antioxidants, which may lead to a reduction of disease risk in remote organs, such as the cardiac pathological remodeling mediated by the TRPC3-Nox2 complex formation