Figure 2.

Genotype function has a nonlinear relationship with cystic fibrosis clinical traits. Left-hand panels for each cystic fibrosis clinical trait plot cystic fibrosis transmembrane conductance regulator (CFTR) genotype function as a percentage of wild type (%WT) on a linear scale against (A) the mean sweat chloride from individuals with that genotype, (B) the percentage of individuals of that genotype who are pancreatic insufficient, (C) the mean FEV₁% predicted for individuals of that genotype, or (D) the mean Kulich normal residual mortality-adjusted (KNoRMA) z-score for individuals of that genotype. The best-fit line is shown. Right-hand panels show CFTR genotype function plotted on a logarithmic scale. Linear regressions for right-hand panels were performed on CFTR function between 0.85% and 50% (black data points). Trait measures from CFTR genotype function outside this range are shown in gray data points. Pearson r value for correlation and P value for deviation of slope from zero are shown for each trait.