Table 3.
Pulmonary Function Tests in Infants at 3 Months of Age
| Vitamin C Mean (SD) (n = 113) | Placebo Mean (SD) (n = 109) | Unadjusted Mean (95% CI) Difference (Vitamin C − Placebo) | Unadjusted P Value | Adjusted Mean (95% CI) Difference (Vitamin C − Placebo)* | Adjusted P Value* | |
|---|---|---|---|---|---|---|
| FEF75, ml/s | 200.7 (71.1) | 188.7 (66.4) | 12.1 (−6.1 to 30.3) | 0.19 | 16.2 (−3.3 to 35.6) | 0.10 |
| FEF50, ml/s | 436.7 (101.5) | 408.5 (94.0) | 28.1 (2.3 to 54.0) | 0.033 | 33.7 (6.1 to 61.3) | 0.02 |
| FEF25–75, ml/s | 387.4 (98.1) | 365.8 (98.8) | 21.6 (−3.8 to 47.0) | 0.096 | 28.1 (0.9 to 55.3) | 0.04 |
| FEV0.5, ml† | 180.0 (35.4) | 173.7 (32.8) | 6.3 (−2.8 to 15.4) | 0.17 | 8.6 (0.7 to 16.4) | 0.03 |
| FVC, ml | 211.2 (43.7) | 207.3 (43.3) | 3.8 (−7.7 to 15.4) | 0.51 | 5.7 (−3.7 to 15.1) | 0.24 |
| FEV0.5/FVC† | 0.80 (0.10) | 0.90 (0.10) | 0.01 (−0.01 to 0.03) | 0.18 | 0.01 (−0.01 to 0.03) | 0.20 |
Definition of abbreviations: CI = confidence interval; FEF25–75 = forced expiratory flow between 25% and 75% of the expired volume; FEF50 = forced expiratory flow at 50% of the expired volume; FEF75 = forced expiratory flow at 75% of the expired volume; FEV0.5 = forced expired volume in the initial 0.5 s.
*
P values and 95% CI adjusted for design factors of site; gestational age at randomization; and covariates of length, race, and sex.
†
Value not reported for one infant.