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. 2019 May 7;10:496. doi: 10.3389/fphar.2019.00496

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Copyright © 2019 Qin, Zhang, Yang, Li, Xu, Yao, Zhang, Gonzalez and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ultra-high-performance liquid chromatography chromatograms and mass spectra of fraxetin and its related glucuronides. (A) UHPLC chromatograms of fraxetin, fraxetin-8-O-glucuronide (G1), and fraxetin-7-O-glucuronide (G2) generated in wild-type HeLa cells and HeLa1A9 cells. (B) electrospray ionization (ESI) mass spectra of fraxetin, G1, and G2 in positive ion mode.