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. 2019 May 7;10:496. doi: 10.3389/fphar.2019.00496

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Copyright © 2019 Qin, Zhang, Yang, Li, Xu, Yao, Zhang, Gonzalez and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentration-dependent excretion of fraxetin-O-glucuronides in HeLa1A9 cells. (A) Excreted fraxetin-8-O-glucuronide (G1) in the extracellular solution at different concentrations of fraxetin (5, 10, and 20 μM). (B) excreted fraxetin-7-O-glucuronide (G2) during treatment with different concentrations of fraxetin (5, 10, and 20 μM). (C) excretion rates of G1 and G2 at different concentrations (5, 10, and 20 μM). Data are expressed as mean ± SD. ^∗,#p < 0.05, ^∗∗,##p < 0.01 or ^{∗∗∗,###}p < 0.001 as compared with fraxetin at 5 or 10 μM.