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Chemical inhibitors Ko143 (5 and 20 μM) and MK571 (5 and 20 μM) exert inhibitory actions on fraxetin-O-glucuronidation activity of UGT1A9. (A) and of the HeLa1A9 cell lysate. (B). Data are expressed as mean ± SD. ∗,#p < 0.05, ∗∗,##p < 0.01, and ∗∗∗,###p < 0.001 in comparison with the control.
