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. 2019 May 7;10:496. doi: 10.3389/fphar.2019.00496

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Copyright © 2019 Qin, Zhang, Yang, Li, Xu, Yao, Zhang, Gonzalez and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of silencing of transporters BCRP and MRPs on the formation and excretion of fraxetin-O-glucuronides in HeLa1A9 cells. (A) The effects of partial silencing of the transporters on the accumulation of fraxetin-8-O-glucuronide (G1) in the extracellular medium. (B) the action of a knockdown of transporters on the excretion of fraxetin-7-O-glucuronide (G2) into the extracellular solution. (C) the influence of a knockdown of transporters on the excretion rates of G1 and G2. (D) effects of partial silencing of transporters on the intracellular G1 and G2 levels. (E) the influence of the knockdown of transporters on the total cellular glucuronidation (G1 and G2) of fraxetin. The concentration of fraxetin was 10 μM. Data are presented as mean ± SD. ^∗,#p < 0.05, ^∗∗,##p < 0.01, and ^{∗∗∗,###}p < 0.001 as compared with the control.