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. 2019 May 1;5(3):e336. doi: 10.1212/NXG.0000000000000336

Figure 1. Clinical identification of incompletely assembled mitochondrial CV from skeletal muscle. A representative image identifying incomplete assembly of mitochondrial CV from skeletal muscle.

Figure 1

Clinical diagnostics of patient mitochondrial enzyme assemblies were performed using in-gel activity staining of BN-PAGE or CN-PAGE. Diagnostic assessments were conducted on patient skeletal muscle tissues with BN-PAGE14,15 performed at University of Colorado Denver Biochemical Genetics Laboratory (n = 3) (Aurora, CO) and CN-PAGE at MNG Laboratories (n = 1) (Atlanta, GA). Representative image pertains to the BN-PAGE cohort (patient 1). BN-PAGE or CN-PAGE = blue-native or clear-native polyacrylamide gel electrophoresis; CV = complex V; MNG = Medical Neurogenetics.