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. 2019 May 7;10:1031. doi: 10.3389/fimmu.2019.01031

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Copyright © 2019 Serrano, Martinez-Flores, Norman, Naranjo, Morales and Serrano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visualization of the 3D structure of B2GP1 from the sides resembling the letter “L” and the letter “J.” (A) “L side” of B2GP1. Three peptides of high antigenicity (P34, P48, and P64) are indicated in orange. The R39-R43 epitope is indicated in red. (B) Visualization of the four previous epitopes in the “J side” of the molecule. Only a part of the P48 corresponding to the angle or “elbow” of the molecule is clearly observed. (C) Visualization of the epitopes of high antigenicity in 4 intermediate steps of the rotation process from the form in L to the form in J. In this process, it can be verified that the part of the P64 observed in the J face corresponds to a group of amino acids that protrude and that are really located in the L face.