Figure 4.

De novo reconstructions of D genes across NAÏVE, HEALTHY, ALLERGY, and HIV datasets. Human D genes that were reconstructed (missed) are shown by colored (gray) cells. Green and orange cells correspond to reconstructed D genes listed in the IMGT database. Green cells correspond to substrings of known D genes. Orange cells correspond to substrings that differ from substrings of known D genes by the first or the last nucleotide. Blue cells correspond to novel variants of D10 (IGHD3-10) and D16 (IGHD3-16) genes. For the Set5, Set7, ALLERGY1–ALLERGY4, ALLERGY17–ALLERGY20, HIV1–HIV13, IgScout inferred two variants (novel and known) of D10 (IGHD3-10). The NAIVE datasets are listed in the increasing order of the number of consensus CDR3s in them.