Figure 5.

De novo reconstructions of D genes across HEALTHY datasets (top) and allelic variants D10⁺ and D16⁺ inferred by IgScout (bottom). (Top) Genes reconstructed at consecutive steps of IgScout for all HEALTHY datasets. Rows correspond to the datasets and columns correspond to the IgScout steps. Each cell is marked by a reconstructed D gene (each D gene is assigned a unique color). Cells marked with the “+” sign refer to strings that differ from known D genes by at most two nucleotides and correspond to putative novel variants (shown in red). (Bottom) Allelic variants D10⁺ and D16⁺ inferred by IgScout. Differences from human D genes and their allelic variants listed in the IMGT database are shown in red.