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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: J Neurochem. 2019 Feb 20;148(6):810–821. doi: 10.1111/jnc.14671

II. Venlafaxine increases the power of carbachol-induced gamma activity in ex vivo hippocampal slices.

II.

2A) Representative local field potential (LFP) recordings from slices obtained from a saline or venlafaxine treated animal. The LFP was filtered in the theta (4–8Hz), low and high gamma (25–55Hz and 65–85Hz respectively) ranges. 2B) The average low and high gamma power of a 315s window beginning 150s after onset of carbachol perfusion was compared between treatment. For n= 4–6 animals, 1–2 slices per animal for each group, there is a statistically significant increase in low and high gamma power for the venlafaxine treated animals (p = 0.008 and 0.05 respectively; Student’s t test). 2C), we show the ratio of post- to pre- carbachol gamma power for each slice. Again we detect a significant difference between slices from wild type saline and venlafaxine treated animals in low gamma (p=0.0246) and a tendency towards significance in high gamma (p= 0.084).