Table 2. Treatment features following melanoma brain metastasis diagnosis.
a
These p values are based only on patients who received the inhibitors.
b
Snapshot mutations include 152 hotspot mutations distributed 15 cancer genes (AKT1, APC, BRAF, CTNNB1, EGFR, FLT3, ERBB2, IDH1, IDH2, JAK2, KIT, KRAS, MAP2K1, NOTCH1, NRAS, PIK3CA, PTEN, and TP53).
Abbreviations: —, no data; BRAFi, BRAF inhibitor; Bx, biopsy; GTR, gross total resection; IMTX, immunotherapy; Ipi, ipilimumab; Ipi‐Nivo, ipilimumab and nivolumab; MBM Dx, brain metastasis diagnosis; PD, disease progression; PD‐1, programmed death 1; PD‐1i, PD‐1 inhibitor; RT, radiotherapy; STR, subtotal resection.