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Distribution of BRAF alterations detected by comprehensive genomic profiling and associated tumor mutational burden. (A): Distribution of BRAF short variant mutations and rearrangements in our set of 385 advanced melanoma cases. (B): Median tumor mutational burden (mutations per megabase) is shown for each subset of cases.Abbreviations: KDD, kinase domain duplication; SV, short variant; TMB, tumor mutational burden
