Figure 3.

Characteristics of cases with BRAF alterations identified using comprehensive genomic profiling (CGP) after prior negative BRAF testing. (A): Characteristics of 29 cases with BRAF alterations identified by hybrid capture‐based next‐generation sequencing (HC‐NGS) after prior negative BRAF result. *Non‐hybrid capture‐based NGS assays. ^#Two samples with activating K601E mutations also has a second activating or uncharacterized BRAF mutation identified. (B): Thirty‐one BRAF alterations identified in 29 patient samples by HC‐NGS after prior negative result. (C): Fraction of cases in which the detected alteration was expected to be covered by the prior test (100% for prior positive, not shown), as well as the fraction of cases for which the same sample was tested by CGP and the prior BRAF test.Abbreviations: F, female; M, male; MAF, mutant allele frequency; NA, not applicable.