Two large randomized controlled trials of glycopyrronium tosylate (GT), a topical anticholinergic, were conducted in adults and children (aged ≥ 9 years) with primary axillary hyperhidrosis. This report presents a detailed evaluation of these trials’ patient-reported outcomes (PROs), which are an important component of therapeutic impact assessment, along with objective measures of sweat production.

In these trials, greater improvements were observed in GT-treated patients than in vehicle-treated patients across all PRO measures.

Previously reported data showed significantly greater reduction in sweat production and sweating severity with GT versus vehicle, along with good tolerability, and the present results indicate that GT provides clinically meaningful benefits. Given these results, GT was approved by the US FDA (29 June 2018) for primary axillary hyperhidrosis in patients aged ≥ 9 years.