Figure 1.

The aortas of progeroid mice exhibit arterial stiffness and inward remodeling. (a) Wire myography analysis of diameter–tension relationships, linear regression slope, and diameter estimated at 100 mmHg for aortic rings (n = 11 Lmna^G609G/G609G mice and n = 13 Lmna^+/+ littermate controls). (b) Magnetic resonance imaging (MRI) of the thoracic aorta in Lmna^+/+mice (n = 19) and Lmna^G609G/G609G mice (n = 17) and quantification of aortic size in area units (mm²) over a complete cardiac cycle. Distensibility is expressed as the slope of the ascending part of the aortic size–time curve