Figure 2.

Mice with VSMC‐specific progerin expression display arterial stiffness and inward remodeling, whereas mice with EC‐specific progerin expression do not. (a, b) Wire myography analysis of diameter–tension relationships, linear regression slope, and diameter estimated at 100 mmHg for each vessel segment in aortic rings from Lmna^LCS/LCSSM22αCre^tg/+mice (n = 11) (a) and Lmna^LCS/LCSTie2Cre^tg/+mice (n = 8) (b). Mice of both genotypes are compared with Lmna^LCS/LCSlittermate controls (n = 13 and 8, respectively)