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. 2019 Mar 18;18(3):e12936. doi: 10.1111/acel.12936

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© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Small mesenteric vessels from ubiquitous and VSMC‐specific progeroid mice exhibit arterial stiffness and inward remodeling. Pressure–diameter curves for the vessel (outer) and lumen (inner) diameters, corresponding stress–strain curves, and representative images of the pressurized arteries at 60 mmHg. (a) Arteries from Lmna^G609G/G609G mice (n = 10), compared with Lmna^+/+littermate controls (n = 9). (b) Arterioles from Lmna^LCS/LCSSM22αCre^tg/+mice (n = 6), compared with Lmna^LCS/LCS littermate controls (n = 6)