Figure 7.

Dietary nitrite supplementation protects Lmna^G609G/G609G mice against vascular stiffness and inward remodeling. (a) Study design. (b) Pressure–diameter curves for vessel (outer) and lumen (inner) diameters, corresponding stress–strain curves, and representative images of the pressurized arteries at 60 mmHg in nitrite‐treated Lmna^{G609G/G609G+/+}(n = 7) and Lmna^+/+ (n = 6) mice. (c) Effect of dietary nitrite supplementation on diameter–tension relationships, slope, and physiological diameter in aortic rings from Lmna^+/+mice (n = 10–14) and Lmna^G609G/G609G mice (n = 9–13). Nitrites attenuate arterial stiffness, as evidenced by increases in the force–diameter slope and the physiological diameter in aortic rings of treated Lmna^G609G/G609G mice