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Effects of GCV treatment on disc aggrecanolysis of p16‐3MR mice. (a) Immunoblot of MMP‐ and ADAMTS‐mediated cleavage of aggrecan of discs of young mice (lanes 1–4), vehicle‐treated old mice (lanes 5–8) and GCV‐treated old mice (lanes 9–12). Graphs on right are quantification of aggrecan fragments shown in panel on left. Data shown are mean ± SD of 4 independent experiments, *p < 0.05
