Table 1.
Top significantly enriched canonical pathways in Mycobacterium avium infected old animal hearts by IPA
| Pathway | −log (p‐Value) | Ratio | Molecules |
|---|---|---|---|
| Granulocyte Adhesion and Diapedesis | 32 | 0.188 | Ccl2,CXCL12,ITGAM,IL1RL1,Ccl8,CSF3R,ITGB2,CCL3L3,THY1,Cxcl11,ITGA1,IL1RN,C5AR1,TNF,CXCL16,CCL4,ICAM2,Ccl7,IL1B,CCL5,TNFRSF1B,CXCL10,FPR2,CCL24,CCL21,CDH5,CCL19,IL18,Ccl9,IL1A,JAM3,PECAM1 |
| Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | 28.1 | 0.119 | IL1RL1,CXCL12,ATF2,FCGR1A,TLR1,SOCS3,TLR9,IL16,MAPKAPK2,FOS,TLR8,C5AR1,TNF,CREBBP,TLR6,TLR2,VEGFC,IRAK1,TLR7,IL1B,CCL5,TNFVEGFA,NFATC1,IL18,MYC,MAP2K4,CCL2,IL1A,MAPK1,SOCS1,FCGR3A/FCGR3B |
| Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 26 | 0.197 | TLR1,TLR9,C3AR1,TLR8,IRF7,C5AR1,TNF,OAS3,TLR6,TLR2,PRKCE,TGFB3,TLR7,IL1B,CCL5,C1QB,OAS2,CASP1,TGFB2,DDX58,IL18,NLRP3,MAP2K4,IL1A,CLEC6A,MAPK1,IFNB1 |
| Toll‐like Receptor Signaling | 23.7 | 0.276 | IL1RL1,IRAK1,SIGIRR,TLR7,IL1B,TLR1,CD14,TLR9,FOS,TLR8,IL18,IL1RN,TNF,MAP2K4,IL1A,TICAM2,MAPK1,TAB1,TLR6,TLR2,ECSIT |
| IL‐10 Signaling | 19.8 | 0.261 | IL1RL1,IL1B,SOCS3,CCR1,CD14,FCGR2A,FOS,CCR5,IL18,IL1RN,FCGR2B,TNF,MAP2K4,IL1A,MAPK1,IL4R,TAB1,IKBKE |
| p38 MAPK Signaling | 19.1 | 0.175 | IL1RL1,IRAK1,TGFB3,ATF2,MAP3K5,IL1B,TNFRSF1B,TGFB2,PLA2G6,FADD,MEF2C,MAPKAPK2,HSPB2,IL18,MYC,IL1RN,TNF,MAP2K4,IL1A,CREBBP,TAB1 |
| IL‐6 Signaling | 18.1 | 0.157 | IL1RL1,IL1B,VEGFA,TNFRSF1B,CD14,TLR9,MAPKAPK2,IL6ST,HSPB2,IL18,PIK3CD,IL1RN,IL1R1,MAP2K4,TNF,MAP2K2,IL1A,SOCS1,MAPK8,HRAS,IKBK |
| NF‐κB Signaling | 18.5 | 0.128 | IRAK1,SIGIRR,PDGFRB,EGFR,TLR7,IL1B,KDR,TLR1,TNFRSF1B,TLR9,FCER1G,,IGF1R,TLR8,IL18,IL1RN,TNF,LCK,IL1A,CREBBP,TAB1,TLR6,TNFRSF11A,TLR2 |
| Atherosclerosis Signaling | 17.3 | 0.157 | CXCL12,IL1B,COL3A1,ITGB2,MSR1,COL1A1,PLA2G6,CMA1,LYZ,IL18,CD36,IL1RN,TNF,CLU,CCL2,IL1A,SELPLG,CSF1,TNFRSF12A,CCR3 |
| Fibrosis/Hepatic Stellate Cell Activation | 24.8 | 0.155 | CCR7,IL1RL1,COL1A1,SMAD4,A2M,CCR5,FN1,TNF,SMAD3,VEGFC,TGFB3,PDGFRB,COL4A1,EGFR,IL1B,CCL5,KDR,TNFRSF1B,CD14,VEGFA,COL3A1,TGFB2,CCL21,IGF1R,CCL2,BCL2,IL1A,CSF1,IL4R |
| Activation of IRF by Cytosolic Pattern Recognition Receptors | 13 | 0.206 | ATF2,STAT2,DDX58,IFIT2,IRF7,MAP2K4,TNF,ISG15,CREBBP,IFNB1,IKBKE |
| IL‐12 Signaling and Production in Macrophages | 11.4 | 0.11 | PRKCE,TGFB3,TGFB2,TLR9,MAF,PPARG,IL23R,FOS,LYZ,IL18,TNF,CLU,MAP2K4,MAPK1,TLR2,IKBKE |
| TGF‐β Signaling | 8.38 | 0.118 | FOS,TGFB3,IRF7,MAP2K4,BCL2,SMAD3,TGFB2,MAPK1,CREBBP,TAB1,SMAD4 |
| HMGB1 Signaling | 7.52 | 0.0863 | FOS,TGFB3,IL18,IL1B,TNFRSF1B,TNF,MAP2K4,CCL2,IL1A,TGFB2,MAPK1,TLR9 |
| Death Receptor Signaling | 7.27 | 0.108 | HSPB2,TNFRSF10A,MAP3K5,TNFRSF1B,TNF,MAP2K4,BCL2,FADD,BID,IKBKE |
| Chemokine Signaling | 6.91 | 0.117 | FOS,CCR5,CXCL12,CCL5,CCL2,CCL24,MAPK1,CCL4,CCR3 |
| Apoptosis Signaling | 6.08 | 0.0938 | PRKCE,MAP3K5,TNFRSF1B,TNF,MAP2K4,BCL2,MAPK1,BID,IKBKE |
| Cardiac Hypertrophy Signaling | 4.97 | 0.0498 | IGF1R,TGFB3,ATF2,MAP3K5,MAP2K4,TGFB2,MAPK1,TLR9,CREBBP,TAB1,MEF2C,MAPKAPK2 |
| IL‐17A Signaling in Fibroblasts | 4.5 | 0.143 | FOS,CCL2,MAPK1,LCN2,IKBKE |