Table 4.

Comparison of hormone levels between non-diabetic addicted (case) and non-diabetic non-addicted (control) male and female rats. Data from seven animals in each group

Hormones	Groups
	Non-diabetic Addicted (Case), (mean ± SEM)			Non-diabetic Non-addicted (Control), (mean ± SEM)
	Male	Female	P-Value	Male	Female	P-Value
T3 (ng/dL)	1.337±0.111	1.561±0.132	0.221	0.872±0.044	1.334±0.041	< 0.001*
T4 (μg/dL)	29.191±2.928	34.220±2.432	0.211	29.557±1.834	32.714±6.625	0.654
17OH-Progesterone (ng/mL)	0.217±0.022	0.734±0.072	< 0.001*	0.251±0.034	1.417±0.091	< 0.001*
Testosterone (ng/mL)	0.261±0.034	0.617±0.041	< 0.001*	0.351±0.037	0.242±0.029	0.041*
DHEA-S (ng/mL)	0. 480±0.081	0.224±0.077	0.042*	0.107±0.034	0.248±0.044	0.028*

The Table 4 shows that in male non-diabetic non-addicted rats, the mean level of T3 was significantly lower than in females (P<0.001). The male non-diabetic addicted rats demonstrated a lower mean level of 17-hydroxyprogesterone and testosterone as compared to female non-diabetic addicted rats (P<0.001 for both comparisons), however, the mean level of DHEA-S was higher (P=0.042). The mean levels of 17-hydroxyprogesterone and DHEA-S were significantly lower in male than in females non-diabetic non-addicted, while testosterone was higher (P≤0.0001, P=0.028 and P=0.041, respectively). *Significance at 0.05 levels.