Figure 1.

Endothelial (Ec) TLR4 prevents age‐related emphysemain in TLR4 ‒/‒ mice. (a) µCT analysis of murine lungs in wild‐type (WT) and TLR4−/− mice. (n = 5 and 7, respectively) *p < 0.05. (b) Lung volumes at 3 months of age from WT, Ec‐TLR4‐transgenic (Tg), TLR4−/−, and Ec‐TLR4‐reconstitution (reconstit) X TLR4−/− mice. (n = 5, 9, 8, and 12, respectively) ***p < 0.001. (c) Mean chord lengths (n = 3 per group) and (d) lung compliance (n = 5 per group) at 3 months of age from WT, TLR4−/−, and Ec‐TLR4‐reconstit X TLR4−/− mice. **p < 0.01, ***p < 0.001. (e) Lung histology of TLR4−/− and Ec‐TLR4‐reconstit X TLR4−/− mice. Arrows point to airspace enlargement