Figure 2.

Endothelial cell (Ec)‐targeted TLR4 silencing (Ec‐TLR4‐sil) in WT lungs is sufficient to cause emphysema. (a) Lung volumes, (b) mean chord lengths, (c) lung compliance (Crs), and (d) H&E stained lung sections of WT mice after 2 months of initial intranasal administration of either Ubiquitin (Ub) or VE‐Cadherin (Ec)‐conjugated RNAi lentivirus with a control (Con) or TLR4 target sequence (Ub‐Con: n = 4, Ub‐TLR4‐sil: n = 6, Ec‐TLR4‐sil: n = 5) *p < 0.05, **p < 0.01 vs. Ub‐Con. Arrows point to enlarged airspaces