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. Author manuscript; available in PMC: 2019 May 14.
Published in final edited form as: Hepatology. 2017 Sep 26;66(5):1601–1615. doi: 10.1002/hep.29265

FIG. 1.

FIG. 1.

Sdc1–/–mice show increased susceptibility to AILI. (A) Wt and Sdc1–/–mice were injected intraperitoneally with APAP (500 mg/kg) or injected intravenously with Con A (25 mg/kg), and serum levels of ALT and AST were measured at 24 hours post-injection. Data shown are mean ± SEM (APAP group: n = 23 for Wt, n = 17 for Sdc1–/–; Con A group: n = 5 for Wt, n = 7 for Sdc1–/–; *P values vs. Wt group, Student t test). (B) Representative H&E-stained liver sections of mice at 24 hours post-APAP (500 mg/kg; original magnification, ×l00). (C) Survival curve of Wt and Sdc1–/– mice injected with 625 mg/kg of APAP (*P vs. Wt, log-rank test).