Table 3.
Patient characteristics by baseline CTC status
| Variable | CTC-negative (n = 13) | CTC-positive (n = 13) | P |
| Histology, % (n)[% of histological subgroup] | |||
| Definite MIFC Benign Borderline MIFC/WIFC MIFC+ |
62% (8) [57%] 8% (1) [25%] 15% (2) [40%] 15% (2) [67%] |
46% (6) [43%] 23% (3) [75%] 23% (3) [60%] 8% (1) [33%] |
0.61 0.43 0.69 0.65 |
| Age, years, mean ± SD | 49 ± 15 | 46 ± 17 | 0.36 |
| Females, % (n) | 77% (10) | 92% (12) | 0.33 |
| Follicular tumor characteristics | |||
| Size, mean ± SD, mm <10.0 mm, % (n) Multifocality, % (n) |
29 ± 21 14% (2) 0 |
40 ± 22 0 8% (1) |
0.20 NA NA |
| Tumor invasion, % (n) | |||
| None Capsular invasion only Vascular invasion only Vascular invasion + capsular invasion Vessels invaded, mean ± SD |
8% (1) 54% (7) 0 38% (5) 0.9 ± 1.7 (n = 12)a |
23% (3) 23% (3) 0 54% (7) 1.6 ± 2.6 (n = 11)b |
0.30 0.111 NA 0.422 0.44 |
| Lymph node involvement, % (n) | |||
| N0 N1a N1b Nx |
15% (2) 8% (1) 0 77% (10) |
46% (6) 0 8% (1) 46% (6) |
0.46 NA NA 0.22 |
| Distant metastasis, n (%) | |||
| Any Lung Bone Other |
0 0 0 0 |
8% (1) 8% (1) 0 0 |
NA NA NA NA |
| RAIT | |||
| None, % (n) 1, % (n) 3, % (n) Cumulative activity, GBq, mean ± SD |
46% (6) 54% (7) 0 1.1 ± 1.2 |
46% (6) 46% (6) 8% (1) 1.9 ± 3.0 |
1.00 0.77 NA 0.38 |
| Stimulated serum Tg, μg/L, at baseline, mean | |||
| ± SD ≥1.0 μg/L, % (n) |
69 ± 225 77% (10) |
23 ± 11 100% (4) |
0.46 0.31 |
| Duration of follow-up, months, mean ± SD | 14 ± 10 | 19 ± 1 | 0.08 |
To convert GBq into mCi, divide by 0.037. Due to rounding, percentages may not add to 100%.
FTUMP, follicular tumor of uncertain malignant potential; MIFC, minimally invasive follicular thyroid carcinoma; MTC, medullary thyroid carcinoma; NA, not [statistically] assessable; PDTC, poorly differentiated thyroid carcinoma; PTC, papillary thyroid carcinoma; RAIT, radioiodine therapy; SD, standard deviation; Tg, thyroglobulin; TgAb, anti-thyroglobulin antibodies.
Due to rounding, percentages may not add to 100%
Excludes 1 patient with “>4” vessels invaded.
Excludes 1 patient with “>4” and 1 patient with a “large” number of vessels invaded
cIncludes 1 patient each with a history of colon cancer or breast cancer