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. 2019 May 14;14(5):e0216732. doi: 10.1371/journal.pone.0216732

Table 2. Percentages of chemsex and drugs used during sex and associations with STI positivity in MSM attending an STI clinic.

All participants (N = 250) STI positive (N = 48) STI negative (N = 202) Outcome: STI positivity
% of total (N) % within groups (N) % within groups (N) Unadjusted OR (95% CI) Adjusted OR (95% CI)a
Main behaviours
Any drug use during sex
Yes 54.4 (136) 23.5 (32) 76.5 (104) 1.89 (0.97–3.65) 1.36 (0.67–2.79)
No 45.6 (114) 14.0 (16) 86.0 (98) 1b 1
Broad definition chemsexc
Yes 34.8 (87) 33.3 (29) 66.7 (58) 3.79 (1.97–7.29)*** 2.92 (1.42–6.01)***
No 65.2 (163) 11.7 (19) 88.3 (144) 1 1
UK definition chemsex
Yes 26.0 (65) 36.9 (24) 63.1 (41) 3.93 (2.03–7.61)*** 2.87 (1.39–5.97)**
No 74.0 (185) 13.0 (24) 87.0 (161) 1
Chemsex-related behaviour based on broad definition of chemsex
Number of different chemsex drugs used <6 months
≥3 18.0 (45) 44.4 (20) 55.6 (25) 6.06 (2.84–12.94)*** 4.13 (1.77–9.62)**
1–2 16.8 (42) 21.4 (9) 78.6 (33) 2.07 (0.86–4.98) 1.92 (0.76–4.87)
0 65.2 (163) 11.7 (19) 88.3 (114) 1 1
Combining chemsex drugs in one sex session
Yes 24.0 (60) 31.7 (19) 68.3 (41) 2.57 (1.31–5.04)* 1.70 (0.81–3.58)
No 76.0 (190) 15.3 (29) 84.7 (161) 1 1
Combining drugs and alcohol (≥4 units) during one sex session
Yes 20.4 (51) 15.7 (8) 84.3 (43) 0.74 (0.32–1.70) 0.47 (0.18–1.21)
No 79.1 (199) 20.1 (40) 79.1 (159) 1 1
Frequency chemsex <6 months
Twice per month or more 16.0 (40) 45.0 (18) 55.0 (22) 6.20 (2.83–13.60)*** 4.23 (1.78–10.05)
Once per month or less 18.8 (47) 23.4 (11) 76.6 (36) 2.32 (1.01–5.30)* 1.99 (0.81–4.91)
Never 65.2 (163) 11.7 (19) 88.3 (144) 1 1
Specific drugs used during sex
Poppers
Yes 42.0 (105) 26.7 (28) 73.3 (77) 2.27 (1.20–4.31)* 1.71 (0.86–3.40)
No 58.0 (145) 13.8 (20) 86.2 (125) 1 1
XTC/MDMA
Yes 27.2 (68) 35.3 (24) 64.7 (44) 3.59 (1.86–6.93)*** 2.67 (1.29–5.56)**
No 72.8 (182) 13.2 (24) 86.8 (158) 1 1
GHB/GBL
Yes 25.6 (64) 35.9 (23) 64.1 (41) 3.61 (1.81–7.00)*** 2.59 (1.24–5.24)*
No 74.4 (186) 13.4 (25) 86.6 (161) 1 1
Cannabis
Yes 22.8 (57) 22.8 (13) 77.2 (44) 1.33 (0.65–2.74) 1.03 (0.47–2.22)
No 77.2 (193) 18.1 (35) 81.9 (158) 1 1
Ketamine
Yes 12.4 (31) 35.5 (11) 64.5 (20) 2.71 (1.20–6.12)* 1.78 (0.74–4.25)
No 87.6 (219) 16.9 (37) 83.1 (182) 1
Speed
Yes 10.8 (27) 25.9 (7) 74.1 (20) 1.55 (0.62–3.92) 1.17 (0.44–3.11)
No 89.2 (223) 18.4 (41) 81.6 (182) 1 1
Cocaine
Yes 9.2 (23) 47.8 (11) 52.2 (12) 4.71 (1.93–11.47)** 3.01 (1.12–8.05)*
No 90.8 (227) 16.3 (37) 83.7 (190) 1 1
Designer drugs
Yes 3.2 (8) 37.5 (3) 62.5 (5) NAd NA
No 96.8 (242) 18.6 (45) 81.4 (197)
Crystal meth
Yes 2.0 (5) 20.0 (1) 80.0 (4) NA NA
No 98.0 (245) 19.2 (47) 80.2 (198)
Mephedrone
Yes 1.6 (4) 50.0 (2) 50.0 (20) NA NA
No 98.4 (246) 18.7 (46) 81.3 (200)
Nitrous oxide
Yes 0.8 (2) 0.0 (0) 100.0 (2) NA NA
No 99.2 (248) 19.4 (48) 80.6 (200)
LSD
Yes 0.4 (1) 100.0 (1) 0.0 (0) NA NA
No 99.6 (249) 18.9 (47) 91.1 (202)
Magic mushrooms
Yes 0.4 (1) 100.0 (1) 0.0 (0) NA NA
No 99.6 (249) 18.9 (47) 91.1 (102)
Substance use during sex
Erection dysfunction drugs
Yes 41.6 (104) 30.8 (32) 69.2 (72) 3.61 (1.86–7.03)*** 2.63 (1.26–5.47)*
No 58.4 (146) 11.0 (16) 89.0 (130) 1 1
Tranquilizers
Yes 8.8 (22) 18.2 (4) 81.8 (13) 0.93 (0.30–2.88) 0.83 (0.25–2.73)
No 91.2 (228) 19.3 (44) 80.7 (184) 1 1

*** <0.001,

** <0.01,

*<0.05

Row percentages are presented.

The use of basecoke, heroin and ritalin during sex in the preceding six months was reported by none of the participants.

a Adjusted for age, HIV status, and number of sex partners in the preceding six months (based on Table 1).

b The reference category is indicated with value ‘1’.

c Drugs included in the broad definition of chemsex: cocaine, crystal meth, designer drugs, GHB/GBL, ketamine, mephedrone, speed, XTC/MDMA.

d NA: groups were too small to calculate odds ratios.