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| Upstream regulator | Fold change | Molecule type | Predicted activation state | Target molecules in dataset | Mechanistic network |
|---|---|---|---|---|---|
| EGR1 | –7.624 | transcription regulator | Inhibited | CCL3L3, CDKN1A, CLU, CXCL2, EGR1, GADD45B, ICAM1, IL1B, PTGS2, SOD2 | 147 (21) |
| ZFP36 | –1.876 | transcription regulator | Activated | CCL3L3, CDKN1A, ICAM1, IL1B, LATS2, PTGS2 | 75 (14) |
| KLF6 | –1.563 | transcription regulator | Inhibited | CCL3L3, CDKN1A, CXCL2, IL1B, PMAIP1, PTGS2, SHH | 82 (13) |
