Table 4.
HFpEF (63 events) |
HFrEF (38 events) |
|||
---|---|---|---|---|
Model | HR (95% CI) † | P-value | HR (95% CI) | P-value |
Age, sex, baseline Gal-3- adjusted | 1.59 (1.18 - 2.13) | 0.0022 | 1.73 (1.36 - 2.19) | <0.0001 |
Multivariable- adjusted* | 1.39 (1.05 - 1.84) | 0.0212 | 1.42 (1.02 - 1.96) | 0.03 |
Multivariable models adjusted for baseline galectin-3 levels, age, sex, systolic blood pressure, antihypertensive treatment, diabetes, body mass index, smoking, left ventricular hypertrophy, high-density lipoprotein (HDL) to cholesterol ratio, estimated glomerular filtration rate, prevalent cardiovascular disease (except for CVD model). Mortality analysis also adjusted for prevalent heart failure.
Hazard ratio and 95% confidence intervals for 1 standard devitaion (SD) increase in log-Gal3 levels over a 10-year period. This corresponds to 3.3 ng/ml change in Gal-3.