Risk of bias	In outcome	In included studies
Low risk of bias	Low risk of bias in all key domains	Most information is from studies at low risk of bias
Unclear risk of bias	Unclear risk of bias for one or more key domains	Most information is from studies at low or unclear risk of bias
High risk of bias	High risk of bias for one or more key domains	The proportion of information from studies at high risk is sufficient to affect the interpretation of results