Date	Event	Description
5 December 2017	New search has been performed	For the update from Al‐Khudairy 2015, we have introduced some changes, broadening the review to fit with the request of the World Health Organization (WHO) Nutrition Guidance Expert Advisory Group (NUGAG) Subgroup on Diet and Health, who requested the update. We included studies in a wider variety of adults, such as those with diabetes or cardiovascular disease at baseline, as the original review was of primary prevention only and excluded diabetes. Effects of dietary changes needed to be assessed over at least one year. We included studies that compared higher omega‐6 fat intake with lower omega‐6 fat intake (not only usual diet). We added new pre‐planned subgroups requested by WHO.
5 December 2017	New citation required and conclusions have changed	The earlier review found no studies examining the effects of either increased or decreased omega‐6 fats on our primary clinical outcomes for cardiovascular disease. For this update we included 19 randomised controlled trials in 6461 participants over 1 to 8 years. We have now included studies reporting all‐cause mortality, cardiovascular deaths and events, coronary heart disease events, major adverse cardiac and cerebrovascular events, and stroke. We have also updated data on long‐term effects of omega‐6 fats on lipids and adiposity, and we have added data on individual cardiovascular events (all secondary outcomes).