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. 2018 Dec 31;2018(12):CD012173. doi: 10.1002/14651858.CD012173.pub2

for the main comparison.

Dietary modifications compared with no modification/placebo for Ménière's disease or syndrome
Patient or population: adults with Ménière's disease or syndrome
Settings: hospital and community
Intervention: dietary modification
Comparison: no modification/placebo
Outcomes Illustrative comparative risks* (95% CI) Relative effect
 (95% CI) No of participants
 (studies) Quality of the evidence
 (GRADE) Comments
Assumed risk Corresponding risk
No modification/placebo Dietary modification
Proportion of patients with control of vertigo or decrease in vertigo attacks No data No data No data No data
Proportion of patients with adverse effects (e.g. hyponatraemia, mood disturbance and headaches) No data No data No data No data
Proportion of patients with loss or gain of hearing/reduction in progression of hearing loss No data No data No data No data
Proportion of patients with a reduction in the severity of tinnitus No data No data No data No data
Proportion of patients with a reduction in the perception of aural fullness No data No data No data No data
Overall changes in well‐being and quality of life No data No data No data No data
Any other adverse effects No data No data No data No data
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 CI: confidence interval
GRADE Working Group grades of evidence
 High quality: Further research is very unlikely to change our confidence in the estimate of effect.
 Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
 Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
 Very low quality: We are very uncertain about the estimate.