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. 2018 Oct 30;2018(10):CD000323. doi: 10.1002/14651858.CD000323.pub3

Comparison 1. Swallowing therapy.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Functional outcome ‐ death or dependency, death or disability at end of trial 2 306 Odds Ratio (M‐H, Random, 95% CI) 1.05 [0.63, 1.75]
1.1 Behavioural interventions 2 306 Odds Ratio (M‐H, Random, 95% CI) 1.05 [0.63, 1.75]
2 Case fatality at end of trial 14 766 Odds Ratio (M‐H, Random, 95% CI) 1.00 [0.66, 1.52]
2.1 Behavioural interventions 2 306 Odds Ratio (M‐H, Random, 95% CI) 0.83 [0.46, 1.51]
2.2 Drug therapy 3 148 Odds Ratio (M‐H, Random, 95% CI) 1.40 [0.31, 6.28]
2.3 Pharyngeal electrical stimulation 4 215 Odds Ratio (M‐H, Random, 95% CI) 0.92 [0.38, 2.26]
2.4 Physical stimulation (thermal, tactile) 1 19 Odds Ratio (M‐H, Random, 95% CI) 1.05 [0.16, 6.92]
2.5 Transcranial magnetic stimulation 4 78 Odds Ratio (M‐H, Random, 95% CI) 0.28 [0.03, 2.93]
3 Length of inpatient stay (days) 8 577 Mean Difference (IV, Random, 95% CI) ‐2.90 [‐5.65, ‐0.15]
3.1 Behavioural interventions 4 370 Mean Difference (IV, Random, 95% CI) ‐2.70 [‐5.68, 0.28]
3.2 Pharyngeal electrical stimulation 4 207 Mean Difference (IV, Random, 95% CI) ‐6.05 [‐16.40, 4.31]
4 Proportion of participants with dysphagia at end of trial 23 1487 Odds Ratio (M‐H, Random, 95% CI) 0.42 [0.32, 0.55]
4.1 Acupuncture 8 676 Odds Ratio (M‐H, Random, 95% CI) 0.31 [0.20, 0.49]
4.2 Behavioural interventions 6 511 Odds Ratio (M‐H, Random, 95% CI) 0.45 [0.28, 0.74]
4.3 Drug therapy 1 17 Odds Ratio (M‐H, Random, 95% CI) 0.48 [0.07, 3.35]
4.4 Neuromuscular electrical stimulation 2 76 Odds Ratio (M‐H, Random, 95% CI) 0.51 [0.18, 1.49]
4.5 Pharyngeal electrical stimulation 3 66 Odds Ratio (M‐H, Random, 95% CI) 0.55 [0.15, 2.11]
4.6 Physical stimulation (thermal, tactile) 2 127 Odds Ratio (M‐H, Random, 95% CI) 0.65 [0.07, 5.85]
4.7 Transcranial direct current stimulation 1 14 Odds Ratio (M‐H, Random, 95% CI) 0.29 [0.01, 8.39]
5 Swallowing ability 26 1173 Std. Mean Difference (IV, Random, 95% CI) ‐0.66 [‐1.01, ‐0.32]
5.1 Acupuncture 6 496 Std. Mean Difference (IV, Random, 95% CI) ‐0.55 [‐1.20, 0.11]
5.2 Behavioural intervention 3 121 Std. Mean Difference (IV, Random, 95% CI) ‐0.56 [‐1.07, ‐0.05]
5.3 Drug therapy 1 71 Std. Mean Difference (IV, Random, 95% CI) ‐0.46 [‐0.93, 0.01]
5.4 Neuromuscular electrical stimulation 2 100 Std. Mean Difference (IV, Random, 95% CI) ‐1.34 [‐3.39, 0.71]
5.5 Pharyngeal electrical stimulation 3 194 Std. Mean Difference (IV, Random, 95% CI) 0.06 [‐0.22, 0.34]
5.6 Physical stimulation (thermal, tactile) 1 16 Std. Mean Difference (IV, Random, 95% CI) ‐0.30 [‐1.29, 0.68]
5.7 Transcranial direct current stimulation 2 34 Std. Mean Difference (IV, Random, 95% CI) ‐0.33 [‐2.22, 1.56]
5.8 Transcranial magnetic stimulation 8 141 Std. Mean Difference (IV, Random, 95% CI) ‐1.29 [‐2.37, ‐0.21]
6 Penetration aspiration score 11 303 Std. Mean Difference (IV, Random, 95% CI) ‐0.37 [‐0.74, ‐0.00]
6.1 Behavioural intervention 1 27 Std. Mean Difference (IV, Random, 95% CI) ‐0.88 [‐1.68, ‐0.08]
6.2 Neuromuscular electrical stimulation 1 18 Std. Mean Difference (IV, Random, 95% CI) 0.57 [‐0.38, 1.52]
6.3 Pharyngeal electrical stimulation 4 177 Std. Mean Difference (IV, Random, 95% CI) ‐0.17 [‐0.53, 0.19]
6.4 Transcranial magnetic stimulation 5 81 Std. Mean Difference (IV, Random, 95% CI) ‐0.53 [‐1.22, 0.16]
7 Chest infection or pneumonia 9 618 Odds Ratio (M‐H, Random, 95% CI) 0.36 [0.16, 0.78]
7.1 Behavioural interventions 6 473 Odds Ratio (M‐H, Random, 95% CI) 0.56 [0.31, 1.00]
7.2 Drug therapy 1 60 Odds Ratio (M‐H, Random, 95% CI) 0.06 [0.01, 0.21]
7.3 Neuromuscular electrical stimulation 1 57 Odds Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7.4 Pharyngeal electrical stimulation 1 28 Odds Ratio (M‐H, Random, 95% CI) 0.43 [0.06, 3.09]
8 Pharyngeal transit time (seconds) 6 187 Mean Difference (IV, Random, 95% CI) ‐0.23 [‐0.32, ‐0.15]
8.1 Drug therapy 1 17 Mean Difference (IV, Random, 95% CI) ‐0.21 [‐0.91, 0.49]
8.2 Neuromuscular electrical stimulation 3 126 Mean Difference (IV, Random, 95% CI) ‐0.23 [‐0.39, ‐0.08]
8.3 Pharyngeal electrical stimulation 1 28 Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.67, 0.37]
8.4 Physical stimulation (thermal, tactile) 1 16 Mean Difference (IV, Random, 95% CI) ‐0.19 [‐0.34, ‐0.04]
9 Institutionalisation 3 447 Odds Ratio (M‐H, Random, 95% CI) 0.75 [0.47, 1.19]
9.1 Behavioural interventions 2 306 Odds Ratio (M‐H, Random, 95% CI) 0.76 [0.39, 1.48]
9.2 Pharyngeal electrical stimulation 1 141 Odds Ratio (M‐H, Random, 95% CI) 0.73 [0.36, 1.48]
10 Nutritional (albumin) 3 169 Mean Difference (IV, Random, 95% CI) 0.37 [‐1.50, 2.24]
10.1 Behavioural interventions 2 64 Mean Difference (IV, Random, 95% CI) 0.20 [‐4.77, 5.17]
10.2 Pharyngeal electrical stimulation 1 105 Mean Difference (IV, Random, 95% CI) 0.40 [‐1.62, 2.42]