Lee 2015.

Methods	Randomisation by computer‐generated random sequence Outcome assessors blinded
Participants	Multi‐centre trial in Hong Kong 93 participants with cerebrovascular disease; onset unclear although study states recent hospitalisation in the previous 3 months Baseline characteristics and prognostic factors similar
Interventions	Rx: lisinopril 2.5 mg once daily at bedtime C: placebo
Outcomes	Incidence of pneumonia, mortality, and Royal Brisbane Hospital Outcome Measure Scale score
Notes	Exclusion: life expectancy < 6 months, baseline systolic blood pressure less than 100 mm Hg, known intolerance to ACE inhibitors, current use of ACE inhibitor or angiotensin receptor blockers, symptomatic chronic lung disease or cardiac failure, frequent withdrawal of enteral tube by patients, serum creatinine > 150 mmol/L, serum potassium > 5.1 mmol/L
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated random sequence
Allocation concealment (selection bias)	Low risk	Allocations concealed by coding files kept confidential to all parties involved until the end of the trial
Blinding (performance bias and detection bias) All outcomes	Low risk	All parties involved not aware of allocation
Blinding of participants and personnel (performance bias) All outcomes	Low risk	All parties involved not aware of allocation
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcome assessor blinded
Incomplete outcome data (attrition bias) All outcomes	High risk	22 participants did not complete trial
Selective reporting (reporting bias)	Low risk	All outcomes reported
Other bias	Low risk	None identified