2. Additional findings.

Analysis	Study	Participants (PCC/FFP)	Notes	Findings
Number of new occurrencesof RBC transfusion	Demeyere 2010	20/20	19 participants allocated to FFP group received 50 units of packed RBCs 16 participants in PCC group received 33 units of packed RBCs	True distribution of packed RBCs per participant unknown because of lack of data (study authors contacted but no reply; Included studies). Hence, trial data were not amenable for meta‐analysis
Transfusion of FFP	Boulis 1999	6/11	6 participants allocated to PCC group received a mean of 399 mL (SD = 271 mL) FFP 11 participants allocated to FFP group received a mean of 2712 mL (SD = 346 mL) FFP	MD ‐2313 mL; 95% CI ‐2611.04 mL to ‐2014.96 mL; participants = 17; studies = 1
	Demeyere 2010	20/20	None of the participants allocated to PCC group received FFP 20 participants allocated to FFP group received a mean of 1372 mL (SD = 320 mL) FFP	Secondary to study design and based on lack of events in PCC group, this study was not included in further analysis of FFP transfusion (Data synthesis; Results)
	Sarode 2013	103/108	None of the participants allocated to PCC group received FFP 108 participants allocated to FFP group received a mean of 813.5 mL (SD = 187.5 mL) FFP	Secondary to study design and based on lack of events in PCC group, this study was not included in further analysis of FFP transfusion
Length of stay in hospital (days)	Sarode 2013	98/104	98 participants in PCC group had mean length of stay in hospital of 4.5 days (SD = 0.55) 104 participants in FFP group had mean length of stay in hospital of 4.2 days (SD = 0.55)	MD = 0.30 days; 95% CI 0.15 days to 0.45 days
Length of stay in ICU (hours)	Sarode 2013	98/104	98 participants in PCC group had mean stay of 0 hours in ICU (IQR 0‐44.7) 104 participants in FFP group had mean stay of 0 hours in the ICU (IQR 0‐40.0)	MD = 0.00 hours; 95% CI ‐0.08 hours to 0.08 hours
Number of complications during inpatient stay not specific to trial intervention	Sarode 2013	103/109	103 participants in PCC group experienced 31 events 109 participants in FFP group experienced 24 events	RR = 1.37; 95% CI 0.86 to 2.16
Amount of bleeding	Demeyere 2010	20/20	No statistical differences in 1 hour, 4 hours and 24 hours postoperative chest tube drainage	1 hour (FFP): mean, mL (SD) 97.0 (± 54.7) 1 hour (PCC): mean, mL (SD) 67.6 (± 46.8) 4 hours (FFP): mean, mL (SD) 163.5 (± 89.8) 4 hours (PCC): mean, mL (SD) 133.5 (± 73.4) 24 hours (FFP): mean, mL (SD) 471.7 (± 294.4) 24 hours (PCC): mean, mL (SD) 439.3 (± 247.3)

CI = confidence interval.

FFP = fresh frozen plasma.

ICU = intensive care unit.

IQR = interquartile range.

MD = mean difference.

PCC = prothrombin complex concentrate.

RBC = red blood cell.

SD = standard deviation.