Date	Event	Description
22 October 2018	New search has been performed	143 references to 40 trials were identified in the searches. We excluded 25 references immediately on title and did not list these in the review. Excluded studies We identified 85 additional references to 25 trials previously listed as excluded in the review (Al‐Aloul 2004; Clancy 2013; Coates 2011; Dorkin 2011; Elborn 2015; Geller 2011; Goss 2009; Griffith 2008; Konstan 2010; Konstan 2011; Mainz 2014; Mazurek 2011; McCoy 2008; Noah 2010; Proesmans 2013; Ratjen 2010; Retsch‐Bogart 2007; Rietschel 2009; Schuster 2013; Stass 2008; Taccetti 2012; Tramper‐Stranders 2009; Trapnell 2010; Treggiari 2011; Wainwright 2002). We identified 13 new trials (30 references) which we have listed as excluded studies (Dasenbrook 2015; Day 1988; Einarsson 2017; Eisenberg 1997; Elborn 2015; Flume 2014; Flume 2015a; Flume 2016; Geller 2004; Herrmann 2017; Kapranov 1995; Nasr 2006; Ruddy 2013). Ongoing studies One trial was identified from clinicaltrials.gov, but is at the recruitment stage so has been listed as an ongoing study (Prevotat 2018). Studies awaiting classification One trial, originally listed as ongoing, has now been completed; but it is a cross‐over trial and no first‐arm data are currently available. The author has been contacted and we have moved the trial to awaiting classification pending a response (Soulsby 2010). One reference to one newly identified trial is listed as awaiting classification (Postnikov 2007). The 'Plain language summary' has been updated in accordance with the latest guidelines and summary of findings tables added.
22 October 2018	New citation required but conclusions have not changed	The previous author team have stepped down and a new review team has taken this review on.