Comparison 1. SmartCare™ versus non‐automated weaning.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Weaning time (randomization to extubation) based on type of control arm	7	495	Mean Difference (IV, Random, 95% CI)	‐2.68 [‐3.99, ‐1.37]
1.1 Predominantly protocolized control strategy	4	325	Mean Difference (IV, Random, 95% CI)	‐2.57 [‐4.26, ‐0.88]
1.2 Predominantly non‐protocolized control strategy	3	170	Mean Difference (IV, Random, 95% CI)	‐2.59 [‐4.75, ‐0.43]