Study	Reason for exclusion
Beale 2007	This 500‐participant trial, identified on a trial registration website, proposed to compare the intensive care unit (ICU) standard ventilator weaning protocol versus the SmartCare™ automated weaning system in patients likely to need mechanical ventilation for a period of 48 hours, but it was never launched
Chen 2008	This non‐randomized trial compared 109 participants who were treated with adaptive support ventilation versus 110 participants whose condition was managed by a respiratory therapist–driven protocol
Donglemans 2007	This trial compared adaptive support ventilation versus pressure control/pressure support in 122 fast‐track coronary artery bypass surgery participants. The trial did not evaluate SmartCare™
Jolliet 2006	This feasibility study was non‐randomized and reported on the use of SmartCare™ during non‐invasive ventilation in participants with acute respiratory failure
Jouvet 2007	This randomized single‐centre trial evaluated SmartCare™ in a paediatric population
Kataoka 2007	This retrospective study reported on the experience of a single centre in using SmartCare™ after off‐pump coronary artery bypass surgery for early extubation
Papirov 2007	This 60‐participant pilot randomized controlled trial (RCT) was designed to compare computer‐driven weaning with SmartCare™ versus physician‐directed weaning in elderly patients at a geriatric rehabilitation hospital and regional weaning centre (non‐ICU setting). To be included, patients had to have stabilization of the acute health problems that prompted admission to the referral hospital. The study was terminated after an undisclosed number of participants had been enrolled because of a request to return the study ventilators. The trial was excluded, as it included exclusively tracheostomized participants (confirmed by study author)
Schadler 2012	This study evaluated SmartCare™ in a postoperative population
Taniguchi 2009	This trial compared manual versus automatic reduction in pressure support in a randomized trial of 106 postoperative participants. The automated system used mandatory rate ventilation with a Taema‐Horus Ventialtor (Air Liquid, France)
Wong 2008	This randomized trial, identified on a trial registration website, was stopped for futility after 3 participants were enrolled over 18 months despite attempts to modify study inclusion criteria