Levy 1997.

Methods	Single‐centre randomized controlled trial, University hospital; France
Participants	Adult surgical and medical participants with septic shock (N = 30)
Interventions	Goal‐directed epinephrine vs norepinephrine + fixed dobutamine (5 mcg/kg/min)
Outcomes	Survival (not further clarified); haemodynamics, tonometry For the mortality analysis, we used data on undetermined mortality
Notes	It is unclear when participants died
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	'According to a randomization code'
Allocation concealment (selection bias)	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not reported
Explicit in‐/exclusion criteria	Low risk	Explicitly described
ITT‐analysis	Unclear risk	Not reported
Adequate patient description	Low risk	Reported
Identical care	Unclear risk	Not reported
Outcome description	Low risk	Implicit
Physicians blinded	Unclear risk	Not reported
Outcome assessors blinded?	Unclear risk	Not reported