Seguin 2006.

Methods	Single‐centre randomized controlled trial, University hospital; France
Participants	Adult participants with septic shock (study authors' definition) Mean age = 66 years, 23% female SAPS II score = 54, SOFA score = 10 (N = 22)
Interventions	Dopexamine (DX) infusion 0.5 mcg/kg/min and norepinephrine (NE) infusion 0.2 mcg/kg/min If cardiac index > 3 L/kg/min, NE increased by 0.2 mcg/kg/min every 3 minutes until MAP 70 to 80 mm Hg If cardiac index < 3 L/kg/min, DX increased by 0.5 mcg/kg/min every 3 minutes until MAP 70 to 80 mm Hg vs Epinephrine infusion 0.2 mcg/kg/min. Increased by 0.2 mcg/kg/min every 3 minutes until MAP 70 to 80 mm Hg
Outcomes	Gastromucosal blood flow (primary), haemodynamics, 28‐day mortality, 90‐day mortality For the mortality analysis, we used data on 90‐day mortality
Notes	Funding: This study was supported by Grant from Rennes University Hospital and Rennes 1 University, 2001 Clinical Research Program, Rennes, France Conflict of interest: none reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Appropriately reported
Allocation concealment (selection bias)	Low risk	Appropriately reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	Appropriately reported
Explicit in‐/exclusion criteria	Low risk	Described explicitly
ITT‐analysis	High risk	Not performed
Adequate patient description	Low risk	Adequately described
Identical care	Low risk	Described
Outcome description	Low risk	Adequately described
Physicians blinded	Unclear risk	No sufficient information
Outcome assessors blinded?	Unclear risk	No sufficient information