Yildizdas 2008.

Methods	Single‐centre randomized controlled trial, University hospital PICU (Paediatric Intensive Care Unit); Turkey
Participants	Paediatric participants with septic shock (Hayden 1994; ACCP/SCCM 1992) and non‐response to fluid resuscitation and high‐dose catecholamines Mean age = 28 months, 47% female PRISM score = 29 (N = 58)
Interventions	Terlipressin bolus 20 mcg/kg every 6 hours up to 96 hours (if MAP < 2 SD for age and at discretion of treating physicians) vs Placebo
Outcomes	ICU mortality, ICU LOS, biochemical markers, mechanical ventilation, haemodynamics, adverse events (digital ischaemias). Urine output narratively described as unchanged within the intervention group, but no numbers or between‐group comparisons presented) For the mortality analysis, we used data on ICU mortality
Notes	Placebo administration not described in sufficient detail Funding: not reported Conflict of interest: not declared
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Open random table
Allocation concealment (selection bias)	High risk	Open random table
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Implicitly reported
Explicit in‐/exclusion criteria	Low risk	Described explicitly
ITT‐analysis	Low risk	Performed
Adequate patient description	Low risk	Described
Identical care	Unclear risk	Catecholamine therapy not described in sufficient detail
Outcome description	Low risk	Clear
Physicians blinded	High risk	Not blinded
Outcome assessors blinded?	Unclear risk	Not reported

ACCP/SCCM = American College of Chest Physicians/Society of Critical Care Medicine; APACHE´= Acute Physiology and Chronic Health Evaluation; ARDS = acute respiratory distress syndrome; AVP = arginine‐vasopressin; CBI = blood clearance of indocyanine green; CI = cardiac index; CV = cardiovascular; EF = ejection fraction; h = hour; ICU = intensive care unit; IDO₂ = index of oxygen delivery; IVO₂ = oxygen consumption, indexed; LOS = length of stay; MAP = mean arterial pressure; MODS = multiple organ dysfunction score; NE = norepinephrine; PCCU = Paediatric Critical Care Unit; PELOD = paediatric logistic organ dysfunction score; PICU = paediatric intensive care unit; PRISM = Paediatric Risk of Mortality score; RCT = randomized controlled trial; SAPS = simplified acute physiology score; SBP = systolic blood pressure; ScvO₂ = central venous oxygen saturation; SIRS = systemic Inflammatory response syndrome; SOFA = sequential organ failure assessment; SOAP = sepsis occurrence in acutely ill patients; SVRI = systemic vascular resistance index; TNFa = tumour necrosis factor alpha; U = units; VASST (study) = Vasopressin And Septic Shock Trial; VEGF = vascular endothelial growth factor; 2SD = standard deviation