Figure 83:

A) Structure of Gd-CP027; B) Gd-CP027 binds to Zn(II) and forms a complex with HSA; C) Glucose sensitive contrast enhanced (GSCE) T₁ weighted MR images at 9.4 T of the prostate of mice during various stages of tumor development: (Bottom) image of a normal healthy prostate (Middle) image of malignant prostate with WD tumor shows clear hypointensity due to the presumable lack of intracellular Zn(II) (top) image of malignant prostate with PD shows no GSCE D) Average GSCE measured over the entire prostate of mice (WD tumor = well differentiated tumors, PD tumor = poorly differentiated tumor). Reproduced from Ref.⁷⁰² (URL: http://www.pnas.org/content/113/37/E5464). Copyright 2016 National Academy of Science.