Table 1:
ECF MRI contrast agents that have been used in the clinic.
| ECF agent (Trade name) | ECF agent (Chemical code) | ECF agent (Generic name) | Approval date |
|---|---|---|---|
| Dotarem, Clariscan | Gd-DOTA | gadoterate meglumine | 1989 (Europe) 2013 (United States) |
| ProHance | Gd-HPDO3A | gadoteridol | 1992 |
| Gadovist (Europe) Gadavist (United States) |
Gd-DO3A-butrol | gadobutrol | 1998 (Europe) 2011 (United States) |
| Magnevista | Gd-DTPA | gadopentate dimeglumine | 1988 |
| Omniscana | Gd-DTPA-BMA | gadodiamide | 1993 |
| Optimarka | Gd-DTPA-BMEA | gadoversetamide | 1999 |
| Multihanceb, c | Gd-BOPTA | gadobenate dimeglumine | 2004 |
a
agents suspended by the European Medicines Agency in 2017.
b
agent available for limited, liver-specific indications in the EU.
c
multipurpose agent that is also suitable for liver imaging.14