. 2018 Dec 4;2018(12):CD011901. doi: 10.1002/14651858.CD011901.pub2

2. Investigations of sources of heterogeneity for studies of visual inspection for detection of BCC.

Test	Datasets	Lesions (BCCs)	DOR (95% CI)	Specificity at 80% sensitivity	Sensitivity at 80% specificity	Relative DOR  (95% CI)	P value  (LR)^a	P value  (Wald)^b
Difference in‐person and image based
In‐person	8	7017 (1586)	11.9 (4.4 to 32.2)	64%	74%	0.45 (0.26 to 9.2)	0.88	0.62
Image	4	853 (156)	18.5 (4.3 to 80.6)	78%	79%	0.45 (0.26 to 9.2)	0.88	0.62
Prevalence
0% ‐ 25%	6	4643 (168)	50.5 (17.1 to 149)	94%	91%	9.7 (2.3 to 40.8)	0.002	0.002
> 25%	6	3227 (1574)	5.2 (2.3 to 11.7)	50%	60%	9.7 (2.3 to 40.8)	0.002	0.002

BCC ‐ basal cell carcinoma; DOR ‐ diagnostic odds ratio; RDOR ‐ relative diagnostic odds ratio; CI ‐ confidence interval; LR ‐ likelihood ratio

^aTests whether there is a difference in test performance between defined groups in terms of either DOR or threshold.  ^bTests the significance of the difference in DOR between defined groups at a particular SROC curve intercept value.